在使用后的不同时间点,口服液中的Delta 9-四大麻醇 (THC) 度:个人参与者的元分析
Scott Macdonald1, Jinhui Zhao2
1Canadian Institute for Substance Use Research (CISUR), School of Health Information Science, University of Victoria, Victoria, BC, Canada.
Heliyon
|November 25, 2024
概括
对delta-9-tetrahydrocannabinol (THC) 的口服液体测试显示,随着时间的推移和使用因素,度有很大变化. 较高的THC水平与剂量增加,频繁使用和吸入管理有关,影响检测准确度.
科学领域:
- 法医毒理学 法医毒理学
- 大麻素的药理动力学.
- 药物测试分析 药物测试分析
背景情况:
- 大麻使用后口服液 (OF) 中的德尔塔-9-四大麻醇 (THC) 度通过元分析并未得到很好的确立.
- 了解OF THC水平对于解释大麻使用和损伤的药物测试至关重要.
研究的目的:
- 为了分析OF THC度的总结统计数据,随着时间的推移,大麻管理后.
- 研究OF THC度与剂量,频率,施用途径,采集装置和性别等因素之间的关系.
- 通过多变量分析来确定这些因素对OF THC水平的独立贡献.
主要方法:
- 进行了对七项经验研究的元分析,其中包括原始的OF THC度数据.
- 研究涉及控制的大麻管理和OF THC的确认测试方法.
- 分析了来自1157个观测的数据.
主要成果:
- OF THC度高度分散,呈阳性倾斜,并随着时间的推移而下降,一些阳性被检测到超过24小时.
- 增加THC剂量,频繁使用大麻和吸入药物与更高的OFTHC度有关.
- DOA拦截装置显示了更高的度,男性性别在双变体分析中显著;其他因素是不确定的.
结论:
- OF THC测试结果受到大麻使用频率和施用方法的影响,影响了之前使用的检测.
- OF测试可以在1.0 ng/mL的截止值下在24小时以后产生积极结果,但不适用于检测损伤.
- 需要进一步研究混因素和研究群体对工作场所应用的代表性.
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