与Helicobacter pylori在美国儿科队列中的抗菌素耐药性相关的因素
Muhammad Riaz1, Christina Chan2, Christine Andrews3
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Oklahoma, Oklahoma City, Oklahoma, USA.
Journal of pediatric gastroenterology and nutrition
|November 25, 2024
概括
在美国儿童中,Helicobacter pylori抗菌耐药性很常见,在耐药性模式和种族,社会经济地位和年龄之间发现了显著的关联. 亚洲儿童表现出更高的抗药性,而较低的收入与甲基醇耐药性相关.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- Helicobacter pylori (H. pylori) 抗菌素耐药性的增加需要了解其在儿童中的流行病学.
- 儿科H. pylori感染需要有效的治疗策略,但由于抗药率的增加,这些策略受到挑战.
研究的目的:
- 在美国儿科队列中调查与H. pylori抗菌素耐药性相关的流行病学因素.
- 确定与儿童H. pylori耐药性模式的人口和临床相关性.
主要方法:
- 在2015年至2022年期间,在新英格兰地区对273名被诊断患有H. pylori感染的儿科患者进行了回顾性队列研究.
- 分析包括描述性统计和后勤回归,以评估患者人口统计,临床因素和抗菌素耐药性数据之间的关联.
主要成果:
- 超过43%的儿科患者对至少一种抗微生物药物表现出耐药性,其中克拉里胺素 (24.5%) 和甲尼达 (21.6%) 的耐药性最为普遍.
- 与白人儿童相比,亚洲儿童的克拉里菌素和整体抗菌素耐药性明显更高.
- 较低的社会经济地位 (家庭收入<30,000美元) 与对甲基醇耐药性的风险增加有关.
结论:
- 儿童的H. pylori抗菌素耐药性与种族和社会经济因素有关.
- 种族和社会经济地位是儿童群体H. pylori治疗策略的关键考虑因素.
- 需要进一步的研究来阐明儿童H. pylori耐药性的机制,并指导针对性的干预措施.
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