怀孕期间出现的阻塞性睡眠呼吸暂停和门诊性血压
Laura Sanapo1,2, Christina Raker3, Basma Merhi1
1Department of Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI, USA.
Sleep
|November 25, 2024
概括
妊娠初期的阻塞性睡眠呼吸暂停 (OSA) 在第三季度与更高的夜间血压 (BP) 和白天心血压有关. 这突出了OSA的重点.
科学领域:
- 产科和妇科 产科和妇科
- 睡眠医学 睡眠医学
- 心脏病学 心脏病学
- 周围生理学 周围生理学
背景情况:
- 夜间血压升高 (BP) 是妊娠高血压疾病 (HDP) 的危险因素.
- 阻塞性睡眠呼吸暂停 (OSA) 是已知的HDP风险因素,但关于其与怀孕期间24小时的门诊血压监测 (ABPM) 相关的数据有限.
- 了解孕期OSA妇女的BP概况对于风险分层和管理至关重要.
研究的目的:
- 为了研究24小时血压概况,特别是夜间血压,在怀孕期间患有OSA的孕妇中.
- 为了比较怀孕开始OSA和没有怀孕的妇女之间的血压测量在第三个三个月.
主要方法:
- 在怀孕13周之前招募超重/肥胖和打的孕妇.
- 在入学时包括家庭睡眠呼吸暂停测试和24小时ABPM,以及怀孕31-34周.
- 排除具有先前存在的OSA的女性;使用多变量线性回归分析来比较群体之间的BP.
主要成果:
- 40%的参与者在第三个三个月内发展出怀孕开始的OSA (呼吸事件指数≥5事件/小时).
- 与对照组相比,怀孕时出现OSA的女性的夜间心和腹血压明显较高,即使对共变量进行了调整.
- 在OSA组中,心血压升高持续到白天测量; 缺乏夜间浸泡是常见的,但在组之间没有显著差异.
结论:
- 在第三个三个月的怀孕开始的OSA与显著增加的夜间和白天心血压有关.
- 这些发现强调了怀疑OSA的孕妇血压监测的重要性.
- 这项研究表明,呼吸事件指数在定义睡眠障碍呼吸病理方面存在局限性,特别是在怀孕期间.
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