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Updated: Jun 6, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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解开GPCRs的阿洛斯特里克调制. 大麻素1受体作为一个案例研究

Alejandro Cruz1, Arieh Warshel1

  • 1Department of Chemistry, University of Southern California, Los Angeles, California, USA.

Proteins
|November 25, 2024
PubMed
概括

这项研究揭示了正调节剂如何与大麻素1型受体 (CB1R) 相互作用. 研究确定了参与CB1R全调节的关键分子机制和残留物,为药物开发提供了洞察力.

关键词:
在GPCRs的全调节过程中.具有约束力的自由能源计算.大麻素1型受体受体1型受体大麻素1型受体积极的全osteric调制.合作因素是合作性的因素.解离常数是一种解离常数.折叠自由能量计算方法

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