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人类牛奶中的金属和金属化物塑造了婴儿微生物群
Eduard Flores Ventura1, Manuel Bernabeu1, Belén Callejón-Leblic2
1Institute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Valencia, Spain. mcolam@iata.csic.es.
Food & function
|November 25, 2024
概括
人类牛奶的金属化物会影响婴儿的肠道细菌,克莱布西埃拉属对金属波动表现出脆弱性. 了解这些相互作用是婴儿发育和健康的关键.
科学领域:
- 人类牛奶金属学
- 婴儿肠道微生物群的发展
- 母婴健康 母婴健康
背景情况:
- 人母乳中的金属化物对婴儿生长至关重要,但它们对婴儿肠道微生物群的影响尚不清楚.
- ,,铁和铜等基本元素在婴儿健康中起着至关重要的作用.
- 调查母乳金属化物成分与生命早期婴儿肠道微生物组之间的联系至关重要.
研究的目的:
- 为了确定母乳中的金属化物含量.
- 评估这些金属化物在产后头两个月内对婴儿肠道微生物群组成的影响.
- 探索特定的金属化物和婴儿肠道中的细菌属之间的相关性.
主要方法:
- 在早期过渡和成熟的哺乳阶段从77个母婴双收集了母乳和婴儿便样本.
- 使用感应合血质谱法 (ICP-MS) 进行人乳的金属学分析.
- 通过16S rRNA amplicon测序分析婴儿肠道微生物群,并使用Spearman的等级相关性来识别金属 (?? 化物) -微生物群关系.
主要成果:
- 在哺乳期之间观察到金属度和微生物丰度/多样性的显著变化.
- 发现了特定金属和肠道细菌之间的相关性,包括婴儿肠道Corynebacterium与牛奶的正相关性,以及Veillonella与抗和Enterobacter与早期哺乳期铜的负相关性.
- 在成熟的哺乳期确定了多个显著的相关性,Klebsiella属与铁,和负相关;辛普森的多样性与铁负相关.
结论:
- 突出了影响婴儿早期发育的重大金属 (?? 化物) -微生物群相互作用.
- 表明婴儿肠道Klebsiella属对母乳金属化物水平的变化特别敏感.
- 建议未来在菌株水平上进行研究,以了解对婴儿健康和发育的影响.
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