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头癌患者癌症生活质量问卷中的临床重要差异最小

Athanassios Kyrgidis^1,2, Athanasia Printza², Evangelos Vitkos³

¹Department of Oral & Maxillofacial Surgery, Aristotle University of Thessaloniki Specialized Cancer Treatment and Reconstruction Center, General Hospital of Thessaloniki "George Papanikolaou", 57010 Thessaloniki, Greece.

Clinics and practice

|November 25, 2024

概括

本研究确定了EORTC QLQ-C30和EORTC QLQ-HN35在头癌患者中的临床重要的最小差异 (MCID),有助于评估生活质量.

科学领域:

在瘤学瘤学.
生活质量研究研究生命质量研究
临床结果评估评估.

背景情况:

头癌对患者的生活质量产生重大影响.
标准化问卷,如 EORTC QLQ-C30 和 EORTC QLQ-HN35,用于衡量这种影响.
确定这些措施的临床上有意义的变化对于患者护理至关重要.

研究的目的:

确定EORTC QLQ-C30和EORTC QLQ-HN35.35临床意义上的变化的大小.
在头癌患者中确定临床重要差异最小值 (MCID).
为评估治疗对生活质量影响提供一个基准.

主要方法:

222名头癌患者在基线和随访期间完成了EORTC QLQ-C30和EORTC QLQ-HN35.
基于 (卡诺夫斯基性能状态) 和基于分布的方法用于计算MCID.
确定了MCIDs,以改善和恶化生活质量.

主要成果:

更多的尺度和症状在恶化患者中显示出统计学上显著的有意义的变化.
对于使用KPS的恶化,EORTC QLQ-C30有意义的变化范围从7.2 (身体功能) 到16.7 (全球健康状况).
为了改善,EORTC QLQ-C30有意义的变化范围从10.0 (角色功能) 到16.7 (全球健康状况).

结论:

这项研究报告了EORTC QLQ-C30和QLQ-HN35在头癌患者中的MCID.
这些MCID使医生能够解释患者的生活质量随着时间的推移而发生的变化.
了解有意义的变化有助于评估治疗对患者福祉的有效性.

关键词:

在 EORTC QLQ-C3030 中,EORTC QLQ-HN3535 QLQ-HN35-HN35-HN35 EORTC QLQ-HN35-HN35 EORTC QLQ-HN35-HN35 EORTC QLQ-HN35-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-HN35 EORTC QLQ-H 最小的临床重要差异.瘤学在瘤学方面.人们的生活质量.

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