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雄激素受体与非编码RNA在细胞癌中的相互作用

Manal A Hussain^1,2, Noha M Elemam^1,3, Iman M Talaat^1,3,4

¹Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.

|November 25, 2024

概括

雄激素受体 (AR) 信号失调非编码RNA (ncRNA),促进细胞癌 (RCC) 的进展. 准AR调节失调的ncRNA为这种流行癌症提供了潜在的治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

细胞癌 (RCC) 是一种流行的泌尿器官癌症,发病率越来越高,特别是在男性中.
与女性相比,患有RCC的男性的死亡率更高,疾病更具侵略性,与与性别相关的风险因素有关.
雄激素受体 (AR) 途径是参与RCC发展的关键生物学因素.

研究的目的:

审查最近关于雄激素受体 (AR) 在细胞癌 (RCC) 中调节失调的非编码RNA (ncRNA) 的作用的发现.
阐明AR影响ncRNA功能和可用性在RCC瘤发生中的分子机制.
探索针对AR-dysregulatedncRNAs作为RCC的治疗策略的潜力.

主要方法:

关于AR信号传递,ncRNA和细胞癌的最新科学文献的综述.
对将AR与癌症进展中的ncRNA失调联系起来的分子机制的分析.
探索基于ncRNA的治疗策略,针对RCC中的AR.

主要成果:

雄激素受体 (AR) 信号显著影响非编码RNA (ncRNA) 的可用性和功能.
通过AR对ncRNAs的失调促进细胞癌 (RCC) 瘤发生和进展.
ncRNAs正在成为AR驱动的RCC病变发生的关键调解者.

结论:

雄激素受体 (AR) 通过调节非编码RNA (ncRNA) 网络,在细胞癌 (RCC) 中起着至关重要的作用.
了解AR介导的ncRNA失调,可以了解RCC的攻击性和性别差异.
准AR调节的ncRNAs代表了新型RCC治疗干预的有希望的途径.

关键词:

受体受体是受体的受体.没有编码的RNAs.细胞癌瘤是细胞癌.尿路生殖系统癌症

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