在轻度认知障碍和主观认知障碍中发生中风或心脏病发作的风险
Michele Lauriola1, Luigi Esposito1, Grazia D'Onofrio2
1Complex Unit of Geriatrics, Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy.
Neurology international
|November 25, 2024
概括
轻度认知障碍 (MCI) 标志着较高风险的重大急性血管事件 (MVEs),如中风和心脏病发作. 早期识别MCI可以帮助预测和潜在地预防这些严重的心血管事件.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 轻度认知障碍 (MCI) 可能作为显著急性血管事件 (MVEs) 的早期指标.
- MVE包括诸如缺血性中风和心肌梗塞 (心脏病发作) 等疾病.
研究的目的:
- 研究轻度认知障碍 (MCI) 作为重大急性血管事件 (MVE) 的预测标记.
- 评估不同认知障碍分类与MVE发生率之间的关系.
主要方法:
- 一项纵向研究招募了181名患者 (平均年龄75.8岁),分为主观认知障碍 (SCI),记忆障碍单一域 (aMCI-SD) 和记忆障碍多域 (aMCI-MD).
- 收集的数据包括临床评估,血管风险因素以及对MVE和痴呆症进展的随访.
主要成果:
- 在两年内,MVE发病率在SCI中为7.4%,在aMCI-SD中为12.17%,在aMCI-MD中为8.57%.
- 急性心肌梗塞发生率为41% (1年) 和29% (2年);缺血性中风发生率为30% (1年) 和40% (2年).
- 患痴呆症的进展在各组之间有显著差异 (p < 0.001),在aMCI-MD中为37%.
结论:
- 轻度认知障碍 (MCI) 反映了全身内皮损伤机制.
- 诊断出MCI是预测主要急性血管事件 (MVEs) 风险升高的预示.
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