相关实验视频

Updated: Jun 6, 2025

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

Published on: May 10, 2019

与年龄相关的听力障碍:基因组和血液甲基组数据整合揭示了候选表观遗传生物标记物

Jie Yu¹, Jingjing Zhu², Hua Zhong³

¹College of Life Science, Fujian Provincial Key Laboratory for the Prevention and Control of Animal Infectious Diseases and Biotechnology, Fujian Provincial Universities Key Laboratory of Preventive Veterinary Medicine and Biotechnology (Longyan University), Longyan University, Longyan, P. R. China.

Omics : a journal of integrative biology

|November 25, 2024

概括

这项研究确定了与年龄相关听力损失 (ARHI) 风险相关的特定DNA甲基化位点 (CpG). 这些表观遗传标记物可能通过调节基因表达来影响ARHI,为精准医学方法铺平了道路.

科学领域:

遗传学是一个遗传学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

与年龄相关的听力损失 (ARHI) 是一个重大的全球健康挑战.
精准医学对于ARHI的预防,诊断和治疗至关重要.

研究的目的:

为了确定ARHI的候选表观遗传标记物.
探索DNA甲基化,基因表达和ARHI风险之间的关系.

主要方法:

在一个大规模的欧洲队列中 (147,997例,575,269例对照) 使用孟德尔随机化与DNA甲基化遗传预测模型.
进行了精细映射分析,以确定可谓的因果CpG位点.
与血液中的附近基因表达相关的CpG甲基化.

主要成果:

确定了1314个与ARHI风险显著相关的CpG地点.
发现了12个可谓的因果性CPG.
在247个CpG和127个基因表达之间观察到显著的相关性.
在甲基化-基因表达-ARHI风险通路中突出显示了37个CpG和18个基因.
确定了三种基因 (PEX6,TCF19,SPTBN1) 富含在听力疾病途径中.

结论:

特定的CpG可以通过调节基因表达来影响ARHI风险.
这些发现支持ARHI精准医学和生物标志物的发展.

关键词:

与年龄相关的听力损伤.老化的老化衰老的老化基于血液的生物标志物在表观基因组学上,表观基因组学.星球健康星球健康精准医学是一门精准医学.

更多相关视频

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Immunolabeling and Counting Ribbon Synapses in Young Adult and Aged Gerbil Cochleae

Published on: April 21, 2022

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

Published on: July 12, 2012

相关概念视频

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.