拉科巴西勒斯 (Lactobacillus rhamnosus GG) 通过降低系统性炎症因子的调节,减轻慢性乙醇暴露小鼠的抑郁类行为和认知缺陷
Xiaoyu Pan1, Anqi Guo2, Kaiyu Guan3
1The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Addiction biology
|November 25, 2024
概括
乳酸细菌 (LGG) 可以改善暴露于慢性乙醇的小鼠的认知和心理健康. LGG有助于恢复肠道微生物群平衡,减少炎症,缓解抑郁症和认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 长期暴露于乙醇 (CEE) 对认知和心理健康产生负面影响.
- CEE改变了肠道微生物群的组成和功能.
- 在缓解CEE引起的疾病中,Lactobacillus rhamnosus GG (LGG) 的潜力在很大程度上是未知的.
研究的目的:
- 在小鼠模型中研究LGG对CEE诱导的认知和精神障碍的治疗效果.
- 阐明涉及肠道微生物群调节和减少炎症的潜在机制.
主要方法:
- 通过免费饮酒建立一个CEE小鼠模型.
- 在CEE的后期阶段给予LGG或抗生素.
- 16S rRNA基因测序用于肠道微生物群分析.
- 评估行为变化 (类似抑郁症的行为,认知障碍).
- 在各种组织中测量炎症因子 (IL-6,IL-1β,TNF-α) 和突触蛋白 (SYN,PSD-95,BDNF).
主要成果:
- CEE显著减少了肠道微生物的多样性,改变了细菌的组成.
- 在CEE小鼠中,LGG和抗生素治疗改善了类似抑郁症的行为和认知缺陷.
- 这两种治疗都降低了大肠,血清和大脑中的炎症标志物.
- LGG和抗生素增加了海马体内突触蛋白 (SYN,PSD-95) 和BDNF的表达.
结论:
- 在CEE小鼠中,LGG有效地减轻了类似抑郁症的行为和认知障碍.
- 通过调节肠道微生物群,减少外围和中心炎症,增强突触可塑性,LGG发挥其保护作用.
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