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Updated: Jun 6, 2025

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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在BRCA1或BRCA2病原性变异载体中,儿童,青少年和年轻成年人患癌症的风险

Shuai Li1,2,3, Laura Madanat-Harjuoja4,5, Goska Leslie3

  • 1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.

Journal of the National Cancer Institute
|November 25, 2024
PubMed
概括

携带BRCA1和BRCA2致病变体的携带者在年轻成年期显著增加患乳腺癌的风险. 然而,他们并没有面临其他儿童或青少年癌症的更高风险,这表明早期基因检测的需求有限.

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