标准化血清25-基维生素D与绝经后妇女下降的相关性
Neil Binkley1, Christopher T Sempos2, Gretta Borchardt3
1Osteoporosis Clinical Research Program and Institute On Aging, University of Wisconsin-Madison, 2870 University Avenue, Madison, WI, USA. nbinkley@wisc.edu.
概括
标准化25-基维生素D水平高达60ng/mL并没有与更年期后妇女下降的增加有关. 然而,60 ng/mL或以上的水平与经历两次或更多次跌倒的可能性更高有关.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 跌倒是绝经后妇女的重大健康问题,往往导致骨折.
- 假设高水平的循环25-氧维生素D (25(OH) D会增加跌倒的风险.
- 目前的指导方针建议保持25OH) D水平低于50ng/mL,但对标准化25OH) D (s25D) 和跌倒的数据有限.
研究的目的:
- 调查标准化25-氧维生素D (s25D) 度与绝经后妇女跌倒风险之间的关联.
- 评估不同s25D级别的跌倒风险,包括超过当前建议的风险.
主要方法:
- 一项为期四年的/维生素D补充剂试验的二次分析,涉及2,303名绝经后妇女.
- 血清25 ((OH) D每年进行测量,并以后进行标准化.
- 跌倒是通过日记记录的,并且≥1和≥2跌倒的发生率是通过跨s25D组 (≤20,20-30,30-40,40-50,50-60和≥60 ng/mL) 的多变量逻辑回归来评估的.
主要成果:
- 在高达60 ng/mL的s25D水平和≥1次跌倒的发生率之间没有发现显著的关联.
- 在s25D组 (p=0.03) 中观察到≥2次跌倒的发生率具有统计学意义的变化.
- 与s25D≥60 ng/mL的女性相比,与s25D≥30-40 ng/mL的女性相比,经历≥2次跌倒的调整后几率几乎翻了一番 (OR=1.99).
结论:
- 标准化25-基维生素D水平高达60ng/mL似乎不会增加绝经后妇女发生一次或多次跌倒的风险.
- 在60 ng/mL及以上的s25D水平下,可能存在多次跌倒 (≥2) 的潜在风险增加.
- 需要在更大,更多样化的队列中进行进一步的研究,以确认非常高的s25D水平与增加的跌倒风险之间的关联.
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