在骨科创伤和关节塑形术中使用带有抗菌素的水泥和珠子的临床实践指南
Aaron B Epperson1, Mohamed E Awad2, Melissa Gorman2
1Department of Orthopedics, University of Colorado Anschutz Medical Campus, 12631 E. 17th Avenue, Mail Stop B202, Aurora, CO, 80045, USA. aaron.epperson@kansascity.edu.
概括
本综述为骨科外科医生提供了关于使用带有抗菌素的水泥和珠子来管理复杂的硬件相关感染的临床指导,以应对日益增长的抗生素耐药性. 它详细介绍了有效的抗微生物选择和输送方法,用于治疗具有挑战性的骨科感染.
科学领域:
- 整形外科手术 整形外科手术
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 整形外科植入物创造了易产生生物膜的环境,导致急性和慢性感染.
- 带有抗菌素的水泥和珠子是常见的治疗方法,但抗菌素耐药性的增加需要探索替代方案.
- 本综述侧重于指导临床决策,用于管理复杂的骨科硬件相关感染.
研究的目的:
- 为骨科外科医生提供临床决策指导,用于管理骨科硬件相关感染.
- 审查当前关于抗微生物加载的水泥和骨科感染的珠子的文献.
- 为了应对在骨科手术中增加抗微生物耐药性的挑战.
主要方法:
- 按照PRISMA指南进行系统审查,搜索PubMed,Ovid MEDLINE和科学网.
- 从74篇文章 (1976-2019) 收集和审查关于剂量,疗效和化概况的数据.
- 确定对抗耐药细菌的第一线,向和非推疗法.
主要成果:
- 详细介绍32种抗生素和3种抗真菌药物对与骨科手术相关的感染有效,包括多药耐药菌株.
- 为各种传递方法 (水泥,珠子) 提供优化载体与抗菌素的比率.
- 描述了骨科植入物中使用的不同抗生素的化和有效性概况.
结论:
- 提供最新的指导方针,用于在骨科水泥和珠子中使用抗微生物药物,用于硬件感染.
- 强调了由于细菌耐药性的演变而导致的建议的动态性质.
- 建议与医疗,传染病和药理学团队合作,以制定机构协议和患者安全.
相关概念视频
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Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...