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Updated: Jun 6, 2025

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在人性化小鼠模型中的filovirus感染

Estefanía Rodríguez1,2, César Muñoz-Fontela1,2, Beatriz Escudero-Pérez3,4

  • 1Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Methods in molecular biology (Clifton, N.J.)
|November 25, 2024
PubMed
概括

研究人员开发了一种新的人类免疫系统 (HIS) 鼠标模型,以更好地研究细菌病毒疾病 (FVD) 和其影响. 这种模型为FVD病理学的临床前研究提供了一个更类似人类的免疫环境.

关键词:
动物模型动物模型菲洛病毒是一种病毒.人类干细胞是人类干细胞.人性化的小鼠.免疫病理学 免疫病理学埃博拉病毒埃博拉病毒.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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