桑 (Fructus mori) 提取物通过调节尿酸载体和调节肠道微生物群来缓解高尿血症
Beicheng Fang1,2, Lu Lu1,2, Minjie Zhao2
1Ningbo Innovation Center, Zhejiang University, Ningbo 315000, China. wangjzju@zju.edu.cn.
Food & function
|November 25, 2024
概括
树提取物通过抑制关键酶和转运体,有效降低高尿血症 (HUA) 模型中的尿酸 (UA). 它还对肠道微生物群产生积极影响,表明它有可能作为HUA的天然治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 自然产品
- 微生物学 微生物学
背景情况:
- 树 (Fructus mori) 是一种传统的中国水果,具有多样化的生物活动.
- 尿酸过高 (Hyperuricemia,简称HUA) 是一种以尿酸水平升高为特征的病症,增加了痛风和其他健康问题的风险.
- 了解自然化合物的机制对于HUA管理至关重要.
研究的目的:
- 在小鼠模型中研究木水提取物 (ME) 的抗超血性活性.
- 阐明 ME 作用的潜在生化和分子机制.
- 探索ME对HUA小鼠肠道微生物群组成的影响.
主要方法:
- 实验室制备的树水提取物.
- 在小鼠中诱导高尿血.
- 尿酸 (UA),肌素 (Cr) 和血液尿素 (BUN) 的生化分析.
- 对促炎因素 (TNF-α,IL-6,IL-8,IL-1β) 的测量.
- 酶活性测定用于丁氧化酶 (XOD) 和腺脱氨酶 (ADA).
- 在脏组织中分析尿酸载体表达 (ABCG2,URAT1).
- 用于肠道微生物群分析的16S rRNA测序.
主要成果:
- 在HUA小鼠中,ME显著降低了血清UA,Cr和BUN水平.
- ME抑制了血清的促炎因素.
- ME抑制了XOD和ADA活动.
- ME调节了脏尿酸载体ABCG2和URAT1.1的表达.
- 高剂量的ME改变了肠道微生物群的组成,显著增加了Ligilactobacillus和Bacteroides等有益细菌.
结论:
- 树提取物在小鼠中显示出显著的抗超血性作用.
- ME通过抑制UA合成酶 (XOD,ADA) 和调节尿酸转运体来减轻HUA.
- ME调节肠道微生物群的能力表明,降低UA的双重机制.
- 这些发现支持了桑提取物作为治疗高尿路血症的治疗剂的潜力.
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