性别确认激素治疗:对心血管风险和血管功能的影响
Kirsty A McGinley1, Angela K Lucas-Herald2, Paul Connelly3
1K A McGinley, School of Cardiovascular and Metabolic Health Sciences, University of Glasgow, Glasgow, UK.
Endocrine connections
|November 25, 2024
概括
性别确认激素治疗 (GAHT) 对跨性别女性和男性的心血管疾病 (CVD) 风险的影响不同. 虽然对跨性别女性有益,但GAHT对跨性别男性有潜在的负面影响,需要进一步研究.
科学领域:
- 心血管科学 心血管科学
- 内分泌学 在内分泌学.
- 跨性别者健康 跨性别者健康
背景情况:
- 性别肯定激素治疗 (GAHT) 对于在性别认同障碍症患者中将二次性特征与肯定性性别对齐至关重要.
- 了解GAHT的血管效应对于管理跨性别人口的长期健康至关重要.
- 血管对GAHT的反应需要详细的研究,因为可能会对心血管产生影响.
研究的目的:
- 系统地审查有关GAHT对血管系统影响机制的现有文献.
- 探索GAHT如何影响跨性别者的心血管疾病 (CVD) 风险概况.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus,Lilacs) 进行了全面的文献搜索,使用与GAHT,心血管疾病风险和跨性别健康相关的关键词.
- 两位独立审查员对研究进行了选,需要与GAHT前,GAHT后或 cisgender人口的队列进行比较.
- 包括的研究的质量评估是使用相关的关键技能评估计划 (CASP) 检查清单进行的.
主要成果:
- 在2564项研究中,69项符合纳入标准,揭示了GAHT对血管的多种影响.
- 变性女性表现出有益的心血管疾病风险概况,包括降低血红蛋白,促炎性标记物和动脉动脉保护性脂质变化.
- 跨性别男性表现出负面的心血管疾病风险变化,例如动脉动脉脂质配置,血红蛋白增加,动脉硬和炎症增加.
结论:
- 目前对跨性别人群非传统心血管疾病风险指标的研究是有限的.
- 不同类型的研究设计,随访损失,样本规模小,缺乏多样性,需要谨慎地解释研究结果.
- 进一步的研究是必不可少的,以澄清变性人群中心血管疾病风险增加的机制以及GAHT作为潜在贡献因素的作用.
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