对于艾滋病毒感染者有认知障碍的人来说,非药物干预:一个范围审查
Lucinda Stuart1, Kate Alford2, Jamie H Vera2,3
1Brighton and Sussex Medical School, Brighton, United Kingdom.
PloS one
|November 25, 2024
概括
计算机化认知训练可能会改善艾滋病毒感染者的认知能力,显示出作为可接受的干预措施的承诺. 需要进一步的研究来证实这些发现,并优化治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 认知障碍 (CI) 影响14%的艾滋病毒感染者,尽管联合抗逆转录病毒疗法 (cART).
- 针对与艾滋病毒相关的CI的非药物干预措施并未特别推,尽管指南强调康复.
- 本综述解决了对艾滋病毒相关CI的非药物干预的证据需求.
研究的目的:
- 描述在艾滋病毒和CI感染者身上检查的非药物干预的类型.
- 审查支持这些干预措施的证据.
主要方法:
- 对2000年1月1日之后发表的研究进行了范围审查.
- 纳入标准:英语语言,成年艾滋病毒感染者群体具有基线CI,没有显著的精神病或物质滥用并发症.
- 从五个电子数据库中确定的研究.
主要成果:
- 14项研究符合纳入标准;弗拉斯卡蒂标准通常用于CI诊断.
- 计算机化认知训练 (CCT) 在九项研究中进行了调查;其他干预措施包括饮食,运动和目标管理培训.
- 八项研究表明,CCT有助于认知改善,有一些持久的效果,尽管并不总是统计学上显著. 患者报告的结局和CCT的可接受性很高.
结论:
- 研究设计,诊断工具和结果衡量的异质性使比较变得复杂.
- 计算机化认知训练 (CCT) 干预措施显示了对认知的潜在益处,并得到了患者的良好接受.
- 需要对更大样本进行进一步的研究,以确定增强结果的特定组件.
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