通过皮肤进行的耳膜迷走神经刺激对初级失眠有效和安全吗? 一个符合PRISMA的系统审查和元分析协议
Ting Yang1, Yunhuo Cai2, Xingling Li3
1Department of Nursing, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, China.
PloS one
|November 25, 2024
概括
这次系统性审查将评估通过皮肤进行耳耳道迷走神经刺激 (ta-VNS) 治疗失眠. 它综合了ta-VNS有效性和安全性的证据,旨在指导这种睡眠障碍的临床实践和研究.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 生物医学工程 生物医学工程
背景情况:
- 失眠是一种广泛的睡眠障碍,严重影响健康和生活质量.
- 现有的失眠治疗有局限性,需要新的治疗策略.
- 通过皮肤进行的耳膜迷走神经刺激 (ta-VNS) 显示出作为治疗失眠的非侵入性神经调节技术的前景.
研究的目的:
- 系统地审查和分析ta-VNS在治疗初级失眠方面的疗效和安全性.
- 提供关于ta-VNS在失眠管理中的当前证据的全面评估.
- 为了告知临床实践和未来的研究方向在失眠治疗.
主要方法:
- 在多个数据库 (Embase,PubMed,Cochrane Library等) 中进行全面的文献搜索. 在2024年12月31日之前.
- 包括成人初级失眠的ta-VNS随机对照试验 (RCT).
- 数据提取,偏差风险评估 (Cochrane RoB 2.0),元分析和证据质量的GRADE评估.
主要成果:
- 本节将介绍包括在内的RCT的综合发现.
- 将提供ta-VNS对失眠症状和相关结果的有效性的定量和定性总结.
- 将分析安全数据,包括与ta-VNS相关的不良事件.
结论:
- 系统性审查和元分析将提供关于失眠的ta-VNS证据的强有力的综合.
- 这些发现将澄清ta-VNS作为初级失眠的潜在治疗方法的疗效和安全性.
- 该研究旨在指导基于证据的临床决策,并刺激对睡眠障碍神经调节的进一步研究.
相关概念视频
01:19Management of Insomnia
231
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
231
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
146
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
146