皮肤碳酸压力与最近出现的2型糖尿病中的神经功能障碍有关
Gidon J Bönhof1,2,3, Alexander Strom2,3, Tobias Jung4,5
1Department of Endocrinology and Diabetology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Diabetes care
|November 25, 2024
概括
先进的糖化终产物 (AGEs) 与2型糖尿病早期的神经损伤有关. 皮肤AGE标志物预测糖尿病感觉运动多神经病变 (DSPN) 的进展.
科学领域:
- 内分泌学和新陈代谢学
- 神经学 神经学
- 皮肤病学 皮肤病学
背景情况:
- 内源性碳烯应激会产生先进的糖化终产物 (AGEs),涉及到糖尿病感觉运动性多神经病变 (DSPN).
- 早期检测和皮肤生物标志物的特征对于理解DSPN病原性至关重要.
研究的目的:
- 为了比较早期2型糖尿病中的皮肤碳酸应激,氧化应激,免疫细胞透和内皮细胞损伤与正常葡萄糖耐受性 (NGT).
- 调查这些皮肤标记物与神经生理缺陷的关联及其对DSPN进展的预测价值.
主要方法:
- 160名近期出现的2型糖尿病患者和144名NGT患者接受了神经功能测试和皮肤活检.
- 皮肤活检分析了皮层内神经纤维密度,AGE自光,阿尔皮里米丁区域和内皮细胞区域.
- 使用AGE阅读器进行了非侵入性AGE测量,并在子组中进行了5年的随访.
主要成果:
- 与NGT相比,Argpyrimidine区域在最近出现的2型糖尿病中显著更高.
- 在2型糖尿病中,AGE自光与神经传导相反相关,与AGE阅读器测量相对正相关.
- 在基线时增加的AGE自光和减少的内皮细胞面积预测了5年内的神经生理学恶化.
结论:
- 皮肤AGE标志物与2型糖尿病早期的神经生理缺陷有关.
- 碳烯压力在DSPN的发展和进展中起着重要作用.
- 这些发现突显了皮肤AGE标志物在早期DSPN诊断和监测方面的潜力.
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