在全国代表性样本中,幻觉使用和大麻使用障碍之间的关联
James M Zech1, David B Yaden2, Grant M Jones3
1Department of Psychology, Florida State University, USA; Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, USA.
Drug and alcohol dependence
|November 25, 2024
概括
迷幻药的使用,包括LSD和psilocybin,与较高的大麻使用障碍 (CUD) 率有关. 这表明,某些迷幻物质可能表明有更大的风险适应不良的大麻使用模式.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 大麻使用障碍 (CUD) 是一个日益严重的公共卫生问题.
- 迷幻药物正在被探索作为药物使用障碍治疗.
- 自然主义迷幻药的使用与CUD之间的联系还没有得到充分的研究.
研究的目的:
- 调查过去一年使用特定迷幻化合物与过去一年CUD之间的关联.
- 检查在全国代表性样本中,心理使用是否预测大麻使用障碍.
主要方法:
- 利用了国家药物使用和健康调查 (2015-2019,2021-2022) 的数据.
- 员工调查加权的多变量物流回归.
- 研究了CUD与使用经典迷幻药物 (LSD,psilocybin,mescaline,peyote,DMT) 和非经典迷幻药物 (ketamine,MDMA) 之间的关联.
主要成果:
- 过去一年的LSD使用和终身psilocybin使用与过去一年CUD的增加率有关 (aRR范围:1.89-2.04).
- 这些关联在中度至严重的CUD (aRR范围:1.65-2.07) 中持续存在.
- 过去一年的LSD使用预测了特定的CUD症状 (aRR范围:1.45-1.73).
结论:
- 研究结果表明,迷幻药物使用与麻醉麻醉使用之间存在关联.
- 某些迷幻药物可能是大麻不适应性使用风险增加的指标.
- 需要进一步的研究来澄清这些复杂的关系.
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