一个孩子的健康开始在怀孕之前和NiPPeR随机试验的结果
Shiao-Yng Chan1,2, Wayne S Cutfield3,4, Keith M Godfrey5,6
1Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Nestle Nutrition Institute workshop series
|November 25, 2024
概括
孕前的营养补充改善了怀孕结果和婴儿健康,减少了早产和婴儿快速体重增加. 这种干预表明了长期抗击慢性疾病的健康弹性潜力.
科学领域:
- 生殖健康 生殖健康
- 孕产妇的营养 孕产妇的营养
- 围产期流行病学 围产期流行病学
背景情况:
- 孕产妇的营养显著影响怀孕和婴儿健康,但对孕前补充剂的证据有限.
- 在受孕之前优化母亲的健康状况对于积极的出生结果和长期后代福祉至关重要.
研究的目的:
- 评估预孕前营养干预对母亲和婴儿健康结果的有效性.
- 评估特定微量营养素,myo-inositol和益生菌配方对妊娠健康和后代发育的影响.
主要方法:
- 多国双盲随机受控试验 (NiPPeR) 涉及预孕和产前补充剂.
- 参与者接受了专门的营养配方或标准微量营养素补充剂.
- 主要结局是孕期血糖;次要结局包括分娩并发症和婴儿生长指标.
主要成果:
- 两组之间没有观察到妊娠血糖的显著差异.
- 这项干预措施显著减少了早产,延迟第二阶段的手术分娩和产后大出血.
- 后代在两岁时表现出减少的快速体重增加和较低的体重指数.
结论:
- 孕前的营养补充可以积极影响怀孕的结果,并减少分娩并发症.
- 这种干预措施显示了减轻婴儿快速体重增加和建立更健康的长期生长轨迹的潜力.
- 怀孕前开始的孕产妇营养干预措施可能会促进对未来非传染性慢性病的抵抗力.
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