多光学纳米电机具有一致的运动方向,用于增强癌症治疗
Wei Zhang1, Yangyang Xiang1, Qi Guo1
1State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province & College of Chemistry and Materials Science, Hebei University, Baoding, 071002, PR China.
Acta biomaterialia
|November 25, 2024
概括
这项研究引入了一种新的pH响应纳米电机,用于深入透癌症干细胞. 多驱动型纳米电机表现出增强的速度和瘤组织透,为先进的癌症治疗提供了潜在的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 纳米药物深入进入固体瘤对于有效的癌症治疗至关重要.
- 目前的纳米引擎在不一致的运动和有限的透力下在复杂的瘤微环境中扎.
- 需要刺激响应的推进机制来增强纳米运动性能和临床转换.
研究的目的:
- 设计和评估一个响应pH的多光学Janus纳米电机 (JMSNs@Pt@P-Au),用于增强深度瘤透.
- 研究H2O2催化,自我电泳和热泳的协同推进机制.
- 评估纳米电机在向固体瘤内的癌症干细胞 (CSCs) 的有效性.
主要方法:
- 用PAA结合的Au纳米粒子半包裹的SiO2@Pt核心@外纳米球的制造.
- 使用内源的H2O2进行催化推进和近红外光进行热泳推进.
- 研究瘤微环境中PAA收缩触发的pH响应性自我电泳.
主要成果:
- 通过联合推进力,JMSNs@Pt@P-Au纳米电机展示了一致的定向运动.
- 在体外和体内实现了增强的速度和通过固体瘤组织的显著透.
- 没有观察到任何不良影响,表明良好的生物相容性.
结论:
- 开发的多理论Janus纳米电机为克服深度瘤透挑战提供了一个有前途的平台.
- 推进模式的刺激响应切换提高了针对癌症治疗的纳米运动效率.
- 这项技术在开发针对CSCs的智能药物输送系统方面具有重大潜力.
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