主要扩散性大B细胞淋巴瘤的Clivus:系统性审查和说明案例示例
Alexander R Evans1, Panayiotis Pelargos1, Chelsey D Deel2
1Department of Neurosurgery, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, USA.
World neurosurgery
|November 25, 2024
概括
主要头骨基淋巴瘤,通常是扩散性大B细胞淋巴瘤 (DLBCL),通常会影响关节,并导致头骨神经VI. 治疗包括活检,化疗和/或放射治疗.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 病理学 病理学 病理学
背景情况:
- 头骨底部的原发性非霍奇金淋巴瘤是罕见的,通常是扩散大的B细胞淋巴瘤 (DLBCL).
- 病变通常发生在关节,经常出现头骨神经 (CN) VI.
研究的目的:
- 报告一个临床DLBCL病例.
- 审查关于头骨基DLBCL的文献.
主要方法:
- 追溯的图表审查和系统的文献搜索 (PubMed,奥维德MEDLINE).
- 提取的数据包括症状学,位置,免疫组织化学和随访.
主要成果:
- 一名71岁的男子患有断层DLBCL,表现为头痛,疲劳,夜间出汗和CN VI.
- 对58名患者的系统性审查显示,临界DLBCL (26%) 和CN VI (33%) 是最常见的.
- 治疗包括活检,亚总切除和化疗免疫疗法 (R-CHOP),导致症状改善.
结论:
- 头骨底部DLBCL通常起源于骨,导致CN VI.
- 这些瘤具有独特的临床和免疫组织化学特征.
- 标准治疗包括活检,然后进行化疗和/或放射治疗.
相关概念视频
Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...


