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Updated: Jun 6, 2025

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稀疏解卷特拉赫兹近场微探针断层扫描,使小固体剂型的非破坏性检查

Matthias Wolfgang¹, Alexander Michalski², Simon Sawallich²

¹Research Center Pharmaceutical Engineering (RCPE) GmbH, Inffeldgasse 13, Graz 8010, Austria.

International journal of pharmaceutics

|November 25, 2024

概括

这项研究引入了先进的特拉赫兹 (THz) 脉冲成像,使用近场微探测器和解卷算法来实现制药涂层的高分辨率分析,即使是厚厚的涂层.

科学领域:

制药科学制药科学
图像技术技术的成像技术
频谱学是一种光谱学.

背景情况:

太赫兹 (THz) 脉冲成像对于固体剂型分析至关重要.
远场THz系统对小或曲线样本的侧面分辨率有限.
制药涂层的厚度各不相同,这给分析带来了挑战.

研究的目的:

开发一种新的THz成像方法,以提高横向分辨率.
改进药物剂型的分析,特别是那些有厚厚涂层的药物剂型.
通过先进的信号处理,使散射介质中的微弱接口能够重建.

主要方法:

使用光导近场微探测器 (PC-NFMs),与THz时间域光谱学集成.
实现了一个修改的稀疏解卷算法用于THz信号处理.
应用该方法来分析具有厚厚涂层的可控释放剂型,作为最坏的情况下.

主要成果:

实现了87微米 (x方向) 和175微米 (y方向) 的高空间分辨率.
成功分析了近400微米厚的制药涂层.
在散射介质中展示了微弱接口的重建.

结论:

新的PC-NFM THz成像方法克服了远场分辨率的限制.
这种技术对于特殊的剂型有价值,包括具有厚厚涂层和迷你片的剂型.
增强的空间分辨率和解卷算法为制药分析提供了重大进展.

关键词:

先进的信号处理系统.非破坏性测试 (NDT) 是指非破坏性测试.光导近场微探测器 (PC-NFM) 是一种光导近场微探测器.质量控制 (QC) 是指质量控制.固体剂量形式固体剂量形式太赫兹脉冲成像 (TPI) 是一种脉冲成像技术.

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