年龄差异对八代人中慢性四肢威胁性缺血结局的影响
Sai Sashank Jagannath Wunnava1, Krishna Ravulapalli2, Tamer El-Sayed1
1Northern Vascular Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, Tyne and Wear, UK.
Annals of vascular surgery
|November 25, 2024
概括
患有慢性四肢威胁性缺血症 (CLTI) 的八十岁患者的结果与年轻患者相似,尽管脆弱性增加. 这凸显了对接受CLTI干预的老年人进行全面评估和风险分层的需要.
科学领域:
- 血管外科 血管外科
- 老年医学 老年医学
- 心血管研究研究心血管研究
背景情况:
- 全球人口老龄化给医疗保健系统带来了重大挑战.
- 多种疾病和衰老是关键的研究领域,特别是老年人慢性四肢威胁性缺血症 (CLTI).
- 关于老年人中CLTI结局的证据有限,尽管人们认为患病率和死亡率很高.
研究的目的:
- 为了研究八十岁以上 (80岁及以上的患者) 患有CLTI的结局.
- 为了比较八十岁的患者和患有CLTI的年轻患者之间的发病率,死亡率和不良事件率.
- 评估虚弱和并发症对老年人中CLTI治疗结果的影响.
主要方法:
- 2020年在英国第三级血管中心连续入院的CLTI病例的回顾性审查.
- 分析包括描述性统计数据和基于年龄的比较.
- 主要结局:生存率 (卡普兰-梅尔分析). 二级结局:主要不良四肢事件 (MALE) 和主要不良心血管事件 (MACE).
主要成果:
- 这项研究包括183名CLTI患者 (平均年龄72岁),其中55人 (30%) 是八旬期患者.
- 八分生的人患糖尿病率较低,但患中风和心房动等并发病率较高.
- 八代人群的中度至重度虚弱率显著更高 (87.3%与57.8%相比).
- 平均存活时间为30个月,年龄组之间没有显著差异 (P=0.406).
- MACE (10.9%对比7.81%) 和MALE (34.5%对比24.2%) 的比率是可比的.
- 八代人不太可能接受开放性手术 (10.9%与25.8%,P=0.024).
结论:
- 与年轻患者相比,患有CLTI的八分生殖器患者在干预后表现出类似的生存,心血管和四肢结果.
- 尽管增加了脆弱性和并发症,但老年人取得了相似的结果.
- 整体评估,术后优化和风险分层对于八十岁人口中管理CLTI至关重要.
相关概念视频
Ischemic Heart Disease: Overview
1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K


