来自医院废水管道的扩展光谱β-乳酸酶产生细菌:使用常见消毒剂进行隔离,表征和生物膜控制
J Wu1, T P Thompson1, N H O'Connell2
1School of Pharmacy, Queen's University Belfast, Belfast, UK.
The Journal of hospital infection
|November 25, 2024
概括
医院的废水含有抗生素耐药细菌,而生物膜会造成感染风险. 有效的消毒剂对于控制这些有弹性的,生物膜形成的扩展光谱β-乳酸酶 (ESBL) 生产细菌在医疗保健环境中至关重要.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 环境健康 环境健康
背景情况:
- 医院的废水系统是抗生素耐药细菌的储.
- 含有扩展光谱β-乳糖酶 (ESBL) 生产微生物的生物膜存在重大感染风险.
研究的目的:
- 调查来自医院废水管道的ESBL产生细菌的抗微生物敏感性和生物膜控制.
- 在爱尔兰的一家三级护理教学医院评估消毒剂对这些细菌的有效性.
主要方法:
- 从废水管道中分离出产生ESBL的细菌.
- 确定抗生素敏感性概况和生物膜形成能力.
- 评估了诸如漂白剂,OptizanTM,VirkonTM和ClinellTM之类的消毒剂的生物膜根除功效.
主要成果:
- 产生ESBL的细菌对β-乳酸具有很高的耐药性.
- 生物膜的形成是多样化的,并受到管道环境的影响.
- 所有测试的消毒剂在推条件下都有效,ClinellTM在所有测试参数中显示出一致的有效性.
结论:
- 从医院废水装置中观察到产生ESBL的细菌的高恢复率.
- 这些细菌形成生物膜的能力凸显了它们作为潜在的感染储库的作用.
- 严格的感染控制实践对于管理这些风险至关重要.
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