Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neural Circuits01:25

Neural Circuits

1.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Oral Lysozyme Attenuates Neuroinflammation and Brain Injury After Traumatic Brain Injury Through Gut Microbiota-Dependent Reprogramming of Tryptophan Metabolism.

CNS neuroscience & therapeutics·2026
Same author

APOE and Cerebral Microbleeds: Insights Into Causal Proteins and Therapeutic Targets.

Brain and behavior·2026
Same author

How do I do it? Laparoscopic extraperitoneal reverse puncture technique for distal catheter placement in ventriculoperitoneal shunting.

Acta neurochirurgica·2026
Same author

Do clock-in for physical exercise in campus help in building undergraduate exercise habits? Evidence from undergraduates in Henan, China.

Frontiers in public health·2026
Same author

Precisely tailoring the d-band center of Pt <i>via</i> metal-semiconductor interaction for C1 small molecule electrooxidation.

Chemical communications (Cambridge, England)·2026
Same author

Synergistic mechanisms of metal-based supports in Ru-based HER catalysts: from dimensional perspective to metal-support interaction engineering.

Chemical science·2026

相关实验视频

Updated: Jun 6, 2025

Studying the Integration of Adult-born Neurons
09:00

Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

13.8K

通过移植的人类神经元进行电路集成.

Qiang Yuan1, Su-Chun Zhang2

  • 1Program in Neuroscience & Behavioral Disorders, Duke-NUS Medical School, Singapore; GK Goh Centre for Neuroscience, Duke-NUS Medical School, Singapore.

Current opinion in genetics & development
|November 25, 2024
PubMed
概括

移植的人类神经元可以整合到大脑电路中,并恢复动物模型中的功能. 细胞身份和外部刺激显著影响这种整合,建议结合细胞治疗和康复以进行神经修复.

更多相关视频

Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips
06:46

Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips

Published on: May 3, 2019

65.9K
Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
15:00

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Published on: May 11, 2019

5.7K

相关实验视频

Last Updated: Jun 6, 2025

Studying the Integration of Adult-born Neurons
09:00

Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

13.8K
Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips
06:46

Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips

Published on: May 3, 2019

65.9K
Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies
15:00

Intraventricular Transplantation of Engineered Neuronal Precursors for In Vivo Neuroarchitecture Studies

Published on: May 11, 2019

5.7K

科学领域:

  • 神经科学是一个神经科学.
  • 再生医学是一种再生医学.
  • 细胞疗法细胞疗法

背景情况:

  • 神经系统疾病和损伤需要有效的修复策略.
  • 细胞移植为持续的生理修复提供了潜力.
  • 成功的细胞疗法需要将移植的神经元整合到现有的神经回路中.

研究的目的:

  • 在动物模型中研究人类多能干细胞衍生的神经前的整合能力.
  • 了解影响移植神经元电路集成的因素.
  • 探索用于增强基于细胞的神经修复治疗结果的策略.

主要方法:

  • 在模型动物的大脑中移植人类多能干细胞衍生的神经祖先.
  • 评估神经元成熟,轴突投射和突触形成.
  • 移植后功能恢复的评估.

主要成果:

  • 移植的不成熟的人类神经元显示出显著的成熟和长距离的轴突投射.
  • 移植的神经元成功地与宿主神经元形成了前和后突触连接.
  • 观察到功能恢复,与成功的神经电路集成相关联.

结论:

  • 移植神经元的电路集成对于神经修复中的功能恢复至关重要.
  • 移植细胞的身份和外部刺激是整合的关键调节者.
  • 优化细胞选择和与康复策略的结合有望改善治疗结果.