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患有类风湿性关节炎的患者血清盖列-3水平:系统性审查和元分析

Mehrdad Mahalleh¹, Amir Hossein Behnoush², Amirmohammad Khalaji³

¹Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran AND Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran. mahallehm80@gmail.com.

Iranian journal of allergy, asthma, and immunology

|November 25, 2024

概括

这项研究发现,与健康人相比,类风湿性关节炎 (RA) 患者的加列-3水平更高. 加勒-3显示出作为RA早期诊断生物标志物的潜力,需要进一步调查.

科学领域:

免疫学免疫学免疫学
生物化学生物化学
类风湿病学类风湿病学

背景情况:

类风湿性关节炎 (RA) 是一种慢性炎症状况,其特征是结膜组织变化和纤维细胞样结膜细胞 (FLS) 增殖.
加勒-3正在成为RA诊断和预后的重要生物标志物.
在RA-FLS患者中高高的加列-3水平有助于炎症,软骨损伤和骨质细胞形成.

研究的目的:

系统地审查和分析关于盖莱克-3作为类风湿性关节炎 (RA) 早期生物标志物的现有证据.
评估循环中的加列-3水平与RA存在之间的关联.

主要方法:

在PubMed,Web of Science,Scopus和Embase进行了系统的文献搜索.
包括的研究比较了RA患者与健康对照组的加列-3水平.
随机效应的元分析被用来计算血清/血加列-3水平的标准化平均差异 (SMD).

主要成果:

包括12项涉及773名RA患者和411名健康对照者的研究.
分析显示,与健康对照人群相比,RA患者的循环盖列-3水平显著更高 (SMD 0.957,95% CI 0.393 到 1.520).
超回归表明,效应大小与年龄,出版年份,样本大小或男性百分比之间没有显著的关联.

结论:

盖莱克-3证明了其作为类风湿性关节炎生物标志物的潜在实用性.
建议进行进一步的研究,以验证galactin-3作为RA早期诊断标记物的作用.

关键词:

盖莱克-3 是一种炎症炎症是一种炎症.类风湿性疾病类风湿性疾病类风湿性关节炎类风湿性关节炎类风湿性关节炎

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