在不同类型的甲状腺癌中,免疫检查点分子的高表达
Mahdi Sajedi Shacker1, Amir Reza Dehghanian2, Razie Kiani3
1Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AND Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. m.sajediimmunology@gmail.com.
Iranian journal of allergy, asthma, and immunology
|November 25, 2024
概括
编程细胞死亡蛋白-1 (PD-1) 和它的配体 (PD-L1) 在甲状腺癌中进行了研究. 这些免疫检查点的较高表达与晚期疾病相关,可能表明联合免疫疗法的作用,特别是在形甲状腺癌中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 免疫检查点分子,如编程细胞死亡蛋白-1 (PD-1) 和其连接体 (PD-L1),在调节免疫反应中起着至关重要的作用.
- 这些检查点的调节失调可能会导致瘤免疫逃避和各种癌症的进展.
- 它们在不同类型的甲状腺癌中的特定作用和表达模式尚未完全阐明.
研究的目的:
- 在不同类型的甲状腺癌中研究PD-1和PD-L1的表达水平.
- 为了将PD-1和PD-L1表达与甲状腺癌患者的临床病理学特征相关联.
- 探索PD-1/PD-L1向免疫治疗在甲状腺癌治疗中的潜力.
主要方法:
- 对100个甲状腺癌组织样本 (乳头癌,卵泡癌,骨髓癌和形甲状腺癌) 的回顾性分析.
- 免疫组织化学被用来检测和量化PD-1和PD-L1表达在瘤细胞和瘤透淋巴细胞 (TILs).
- 进行了统计分析,以将表达水平与临床病理特征和瘤类型联系起来.
主要成果:
- 在TILs (88%) 和瘤细胞 (28%) 中检测到PD-1,而在瘤细胞 (30%) 和TILs (79%) 中检测到PD-L1.
- 与其他亚型相比,形甲状腺癌 (ATC) 的PD-1和PD-L1表达显著更高.
- 增加的PD-1和PD-L1表达与晚期,较大的瘤大小,瘤缩和较高的线粒分裂率显著相关.
结论:
- PD-1和PD-L1在各种甲状腺癌中表达,在ATC中观察到更高的水平.
- 它们的表达与侵略性的临床病理特征有关,这表明它们在瘤进展中的作用.
- 针对PD-1和PD-L1的联合免疫疗法可能代表甲状腺癌,特别是ATC的有前途的治疗策略.
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