在多发性骨髓瘤患者的基于人口的匹配样本中,根据种族比较结果
Breanna B Greteman1, Michael H Tomasson2, Amanda R Kahl3
1Department of Epidemiology, University of Iowa College of Public Health, 145 N Riverside Dr., S453 CPHB, Iowa City, IA, 52242, USA.
Cancer causes & control : CCC
|November 25, 2024
概括
在爱荷华州,多发性骨髓瘤 (MM) 发病率和死亡率存在种族差异. 然而,在对年龄和位置进行匹配后,在黑色和白色MM患者之间没有发现显著的生存差异.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 多发性骨髓瘤 (MM) 治疗和生存的种族不平等是显而易见的,特别是在中西部.
- 年龄和地理位置显著影响了MM的治疗和预后.
研究的目的:
- 在爱荷华州调查多发性骨髓瘤 (MM) 治疗和生存的种族差异.
- 通过根据年龄和地理位置匹配患者来确定结果差异的原因.
主要方法:
- 来自爱荷华州癌症登记处的成年患者被诊断为第一个初级MM (2010-2019) 的回顾性分析.
- 根据年龄和居住城市,与每个黑人患者匹配最多4名白人患者.
- 使用考克斯比例危险模型对人口特征和生存率进行比较.
主要成果:
- 总体样本包括1845名患者 (85名黑人,1760名白人);321人被匹配.
- 总体样本中的黑人患者显示MM特异性死亡风险降低 (HR=0.50).
- 在黑人患者和匹配的白人对照者之间没有观察到MM特异性死亡的统计学上显著差异 (HR=0.72). 没有发现治疗差异.
结论:
- 尽管在爱荷华州MM发病率和死亡率上存在种族差异,但在年龄和居住地相匹配时,没有生存差异.
- 这些发现表明,爱荷华州的MM治疗没有主要障碍,可以为预防策略提供信息.
- 进一步的研究应该探索其他地理区域和死亡率差异的原因.
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