相关实验视频

Updated: Jun 6, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

心肌病的表观遗传学:下一个前沿

Aida Hajdarpašić¹, Martijn Tukker², Wouter Te Rijdt³

¹Department of Medical Biology and Genetics, Sarajevo Medical School, University Sarajevo School of Science and Technology, Hrasnička Cesta 3a, 71210, Sarajevo, Ilidža, Bosnia and Herzegovina. aida.hajdarpasic@ssst.edu.ba.

Heart failure reviews

|November 25, 2024

概括

表观遗传学,而不仅仅是遗传学,影响心肌病 (CMP). 环境因素和表观遗传变化,如DNA甲基化和基因组修饰,影响了CMP的发展,提供了新的诊断和治疗点.

科学领域:

心血管医学心血管医学
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

心肌病 (CMP) 包含各种心肌疾病,具有复杂的结构和功能变化.
仅仅是基因突变并不能完全解释CMP的临床表型和进展,即使在遗传形式.
表观遗传机制和环境因素显著调节CMP的临床表达和与年龄相关的透度.

研究的目的:

审查表观遗传失调在心肌病中的作用.
探索环境对CMP表观遗传修饰的影响.
突出表观遗传学在CMP中的潜在诊断和治疗应用.

主要方法:

在CMP中对DNA甲基化,基因组修饰,染色质重塑和非编码RNA的文献综述.
对环境暴露的分析及其对CMP相关的表观遗传变化的影响.
对单双双胞胎和代际研究进行讨论,以了解基因-环境-表观遗传相互作用.

主要成果:

表观遗传因素,包括DNA甲基化和基因组修饰,都与CMP的发展和恶化有关.
环境暴露可以改变表观遗传特征,影响CMP的发病和进展.
表观遗传修饰显示出作为CMP诊断的生物标志物和新疗法的标的潜力.

结论:

表观遗传学在CMP的发病过程中起着至关重要的作用,修改遗传倾向.
环境因素与表观遗传机制相互作用,影响CMP的变性.
针对表观遗传途径为个性化CMP预防和治疗策略提供了有希望的途径.

关键词:

心肌病是一种心肌病.临床表达方式临床表达环境环境环境环境表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.基因型基因型基因型现象型现象型是一种表现型.

更多相关视频

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

Published on: June 7, 2018

相关概念视频

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

Genomic Imprinting and Inheritance

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...