前额前谷氨基基功能的降低与治疗耐药性抑郁症中星球细胞相关基因表达的减少有关
Masataka Wada1,2, Shinichiro Nakajima3, Shiori Honda1
1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Translational psychiatry
|November 25, 2024
概括
治疗耐药性抑郁症 (TRD) 在脊侧前额叶皮层 (DLPFC) 中显示出降低的谷氨酸性神经活动. 这种功能障碍,通过跨磁刺激-脑电图 (TMS-EEG) 测量,可能与天体细胞异常有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经生理学 神经生理学
背景情况:
- 谷氨酸功能障碍与治疗耐药性抑郁症 (TRD) 病理生理学有关.
- 对TRD的体内生理研究是有限的.
- 超磁刺激-电脑电图 (TMS-EEG) 评估皮质内促进 (ICF),反映了谷氨酸的功能.
研究的目的:
- 在TRD患者和健康对照者 (HCs) 之间,在背侧前额叶皮层 (DLPFC) 中比较谷氨基质功能 (通过ICF TMS-EEG).
- 通过虚拟组织学研究细胞特异性基因表达和谷氨基质神经传播差异之间的关系.
主要方法:
- 60名TRD参与者和30名HC在左侧DLPFC接受了ICF TMS-EEG.
- 计算了传感器和源级ICF测量结果.
- 空间相关性分析将ICF活动与艾伦人类大脑图谱中的基因表达联系起来.
主要成果:
- 在TRD和HC组之间,传感器级DLPFC-ICF没有显著差异.
- 与HC相比,TRD组的源级DLPFC-ICF减少了 (p=0.026). 在TRD组中,源级DLPFC-ICF减少了.
- 在TRD中减少ICF信号传播与天体细胞特异性基因表达相关 (p<0.0001).
结论:
- 在左侧DLPFC中由ICF索引的Glutamatergic神经活动在TRD中下降.
- 在TRD中减少的谷氨酸质信号传播可能与天体细胞异常有关.
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