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Updated: Jun 6, 2025

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在小鼠中通过Lnc-Atg16l1的干环变化促进TLR7-MyD88依赖性炎症和自身免疫

Zongheng Yang1, Shuchen Ji1, Lun Liu1

  • 1Department of Immunology, Center for Immunotherapy, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Nature communications
|November 25, 2024
PubMed
概括

一种新的长非编码RNA,Lnc-Atg16l1,充当分子支架,使用结构变化来增强托尔类受体7 (TLR7) 信号传递. 这一发现为自身免疫性疾病机制和潜在的治疗点提供了新的见解.

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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