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Ad26.RSV.preF完全保护小牛免受由牛RSV挑战引起的严重呼吸道疾病

Leslie van der Fits¹, Rineke de Jong², Karin Dijkman^3,4

¹Janssen Vaccines & Prevention B.V., Leiden, The Netherlands. lfits@its.jnj.com.

|November 25, 2024

概括

Ad26.RSV.preF疫苗在年轻的小牛中具有免疫性,可以防止严重的牛RSV疾病. 这种临床前模型表明,年轻动物对呼吸系统疾病具有广泛的免疫力.

科学领域:

疫苗学疫苗学疫苗学
病毒学病毒学
临床前模型临床前模型

背景情况:

人类和牛RSV (bRSV) 具有遗传和临床相似性,使得bRSV感染成为研究RSV病变的相关模型.
以前的研究表明Ad26.RSV.preF疫苗在RSV阳性成年人中的有效性和婴儿的免疫性.

研究的目的:

评估Ad26.RSV.preF疫苗在使用年轻,血清阴性小牛的临床前模型中的有效性.
评估疫苗诱导抗牛RSV保护性免疫的能力.

主要方法:

年轻的小牛用Ad26.RSV.preF或安慰剂免疫.
动物随后受到bRSV.的挑战.
挑战后评估了临床症状,病毒载量和肺病理.

主要成果:

Ad26.RSV.preF免疫诱导了对人类和牛RSV的中和抗体,以及细胞免疫反应.
接受安慰剂治疗的小牛经历了严重的呼吸困扰,高的病毒载荷和显著的肺病理,导致大多数动物的预先终结.
接种疫苗的小牛表现出轻微的临床症状,显著降低病毒载量和最小的肺病理,完成了这项研究.

结论:

Ad26.RSV.preF在年幼的小牛中具有免疫性.
该疫苗在严格的异种bRSV挑战模型中显示出有效性.
Ad26.RSV.preF诱导广泛的保护性免疫力,抵抗严重的RSV相关疾病.

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