2型糖尿病诊断时的年龄和美国人口中死亡风险
Hong-Jin Zhang1, Jie Feng2, Xiang-Tao Zhang2
1Department of Cardiovascular Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
年轻时被诊断为2型糖尿病 (T2DM)? 这显著增加了心血管和整体死亡率的风险. 早期T2DM诊断与较差的生存结果有关,突出显示了预防的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 在T2DM诊断时年龄对长期死亡风险的影响需要进一步调查.
研究的目的:
- 调查T2DM诊断时的年龄与心血管和全因死亡率之间的关联.
- 评估美国人口中不同诊断年龄组的死亡风险.
主要方法:
- 利用了1999-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 包括8654名被诊断患有糖尿病的参与者.
- 采用加权多变量考克斯回归分析,子组和灵敏度分析.
主要成果:
- 在T2DM诊断时的年龄较小与全因死亡风险增加有关.
- 早期发病的T2DM (年龄<40岁) 与晚发病的T2DM (年龄≥60岁) 相比,所有原因死亡率的危险比为2.72.
- 随着年轻的诊断年龄,也观察到较高的心血管疾病死亡风险.
结论:
- 在T2DM诊断时的年龄较小是增加死亡率的重要风险因素.
- 这些发现强调了早期T2DM预防策略的关键重要性.
- 诊断年龄和死亡风险之间的关联在吸烟者和高血压患者中被放大.
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