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Updated: Jun 14, 2026

Modeling Chemotherapy Resistant Leukemia In Vitro
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Modeling Chemotherapy Resistant Leukemia In Vitro

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一个多原子图谱识别了T细胞急性淋巴细胞白血病中一种耐治疗的,骨髓原始细胞样细胞群

Jason Xu1,2, Changya Chen3,4, Jonathan H Sussman1,2

  • 1Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nature cancer
|November 25, 2024
PubMed
概括

在T细胞急性淋巴细胞白血病 (T-ALL) 中识别骨髓原始体 (BMP) 样白血病亚群对于理解治疗失败至关重要. 这一发现使得高风险T-ALL患者的向治疗成为可能.

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Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow07:21

Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow

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Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...