在宿主内持续存在的SARS-CoV-2的后果
Alex Sigal1,2,3, Richard A Neher4,5, Richard J Lessells6,7
1The Lautenberg Center for Immunology and Cancer Research, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. alexander.sigal@mail.huji.ac.il.
在免疫功能低下的人群中,持续的SARS-CoV-2感染可能导致病毒演变和新变异. 这篇评论探讨了病毒的持久性,它与变种的联系,以及在长期COVID中的潜在作用.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2通常会导致急性呼吸道感染,但一些免疫受损的个体会出现持续性感染.
- 持续的SARS-CoV-2复制可以导致突变的快速积累,可能导致新变异的演变.
- 持续的SARS-CoV-2复制在长期COVID的发展中的作用仍然存在争议,尽管在各种身体部分检测到了病毒物质.
研究的目的:
- 审查SARS-CoV-2病毒持续性的机制.
- 检查持续的SARS-CoV-2感染中宿主内部进化的过程.
- 探索持续性感染,SARS-CoV-2变种的出现和长期COVID的病理生理学之间的联系.
主要方法:
- 审查有关SARS-CoV-2持续性和演变的现有文献.
- 对研究持续性感染中病毒分泌和突变积累的研究进行分析.
- 检查证据,将病毒持久性与长期COVID症状联系起来.
主要成果:
- 持续的SARS-CoV-2感染促进了加速的病毒进化,可能导致抗体逃逸和增强细胞感染.
- 广泛突变的SARS-CoV-2变种的出现可能受到单个个体内的进化的影响.
- 虽然在长期COVID病例中,病毒RNA和蛋白质在初始感染后很长时间才被发现,但复制能力强的病毒尚未从免疫能力强的个体培养出来.
结论:
- 了解病毒持久性对于理解SARS-CoV-2病理生理学和变种的出现至关重要.
- 持续的SARS-CoV-2感染可能在长期COVID的发展中发挥重要作用.
- 对病毒持续性的洞察力可能对管理其他新出现的病毒性疾病有更广泛的影响.
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