孕期和产后早期的蛋白质营养不良会破坏 rhesus 的神经发育
Joshua A Karpf1, Elinor L Sullivan1,2, Victoria H J Roberts3
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, United States.
Cerebral cortex (New York, N.Y. : 1991)
|November 26, 2024
概括
怀孕期间母亲的蛋白质减少会影响胎儿的大脑发育,导致后代的灰色和白质异常. 这些神经发育的变化可能会影响早期的运动发育.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 孕期母亲的营养对于胎儿的神经发育至关重要.
- 怀孕期间的蛋白质缺乏与后代的神经和行为障碍有关.
- 非人类灵长类动物的妊娠蛋白减少模型提供了对人类神经发育效应的见解.
研究的目的:
- 研究母体蛋白质摄入量减少对 rhesus macaque 胎儿和新生儿大脑发育的神经发育影响.
- 为了识别由母体蛋白质限制导致的灰色和白质的结构和组织变化.
- 为了将观察到的神经成像发现与早期行为评估相关联.
主要方法:
- 纵向胎儿和新生儿磁共振成像 (MRI) 评估从怀孕中期到11个月大.
- 使用一种非人类灵长类动物模型 (Macaca mulatta) 以已建立的妊娠蛋白减少饮食 (33%和50%的减少).
- 采用扩散加权成像来评估白质完整性 (微分异型) 和结构性MRI用于灰质分析.
主要成果:
- 与对照组相比,在两组蛋白质减少组中都观察到结构异常.
- 在50%蛋白质减少队列中,观察到与年龄相关的全脑体积缺陷,主要是灰色物质 (皮质/皮下皮质,小脑).
- 产后扩散加权成像显示,白质分数异构的广泛减少,特别是在体中,对于两个减少的蛋白质组.
结论:
- 妊娠期间减少母亲的蛋白质摄入量会导致后代大脑发育的显著结构和组织变化,影响灰质和白质.
- 神经成像检测到实质性的神经发育变化,即使早期的行为评估只显示轻微的干扰.
- 这些发现强调了充分的母体蛋白质摄入对于正常的大脑形成和组织的关键作用,这可能对早期运动发育产生潜在影响.
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