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在健康参与者中,急性梅斯卡林的安全药理学

Aaron Klaiber^1,2,3,4, Mélusine Humbert-Droz^1,2,3,4, Laura Ley^1,2,3,4

¹Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland.

British journal of clinical pharmacology

|November 26, 2024

概括

在临床试验中,高达800mg的单剂梅斯卡林在健康人群中似乎是安全的. 这项研究为心理健康状况的潜在迷幻疗法提供了关键的安全数据.

科学领域:

心理药理学心理药理学
临床心理学临床心理学
神经科学是一个神经科学.

背景情况:

迷幻药,包括梅斯卡林,在治疗抑郁和焦虑方面表现有前途.
对于梅斯卡林的治疗用途,安全性数据有限.

研究的目的:

评估单次口服剂量梅斯卡林的安全性和耐受性.
在受控环境中评估梅斯卡林的急性心理和身体影响.

主要方法:

两个双盲,随机,安慰剂对照研究的综合分析.
在48名健康参与者中,给予96次梅斯卡林 (100-800毫克).
对主观,自主和不良影响的监测,以及血液检查和"闪回".

主要成果:

积极的主观影响随剂量增加而增加,并且超过负面影响.
自主活动中适度增加;没有严重的血压升高.
恶心是剂量限制的;肝/功能和血液细胞计数保持正常.
在2%的管理中报告了"闪回".

结论:

在受控的临床环境中,高达800mg的单次梅斯卡林剂量是安全的.
在健康的参与者中没有观察到明显的急性心理或身体伤害.
根据安全概况,对梅斯卡林治疗潜力的进一步研究是有必要的.

关键词:

血压血压血压血压身体的温度身体的温度回忆中的闪光回忆.心率是指心率是如何发生的.梅斯卡林 (Mescaline) 是一种可怕的药物.在安全方面,安全是安全的.主观影响是主观的影响.

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