过去广泛的病对便calprotectin在性结肠炎中的影响
Natsuki Ishida1, Takatoshi Egami2, Tomohiro Takebe2
1First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Chuo-ku, Shizuoka, Hamamatsu, 431-3192, Japan. ma03006@hama-med.ac.jp.
BMC gastroenterology
|November 26, 2024
概括
便中calprotectin (FC) 在性结肠炎 (UC) 患者中升高,这些患者过去有广泛的 (PEU),即使在缓解期间. 在这些患者中,FC可能无法准确预测复发.
科学领域:
- 胃肠病学 胃肠病学
- 炎症性肠道疾病研究研究
- 生物标记分析 生物标记分析
背景情况:
- 性结肠炎 (UC) 的特点是肠道炎症和.
- 过去广泛的 (PEU) 是UC患者的一个重要特征.
- PEU对便中calprotectin (FC) 水平的影响需要进一步调查.
研究的目的:
- 调查过去广泛的 (PEU) 对便中calprotectin (FC) 水平的影响,性结肠炎 (UC) 患者.
- 评估FC作为预测UC患者有或没有PEU的临床复发的生物标志物的实用性.
主要方法:
- 这是一项对61名UC患者进行的回顾性,单中心的观察性研究.
- 患者分为PEU (痕或伪多重症) 和非PEU组.
- FC,体免疫化学试验 (FIT),C反应蛋白 (CRP),血红蛋白和白蛋白水平的比较;对12个月临床复发的评估.
主要成果:
- 与没有PEU的患者相比,患有PEU的UC患者表现出明显更高的C-反应蛋白和FC水平.
- 在12个月内,FC值显示了临床复发和缓解组之间的显著差异.
- 预测复发的FC截止值为所有患者和非PEU组的118 mg/kg,但FC没有预测PEU组的复发.
结论:
- 性结肠炎患有PEU的患者表现出升高的FC水平,无论其缓解状态如何.
- 便calprotectin可能不能作为一个可靠的生物标志物来预测复发UC患者有广泛的病史.
- 需要进一步的研究来确定准确的生物标志物来监测PEUs的UC患者的疾病活动.
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