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低老年人营养风险指数与患有2型糖尿病的老年患者的骨质缩症有关
Xiaoye Duan1, Jagadish K Chhetri2, Lina Sun1
1Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
BMC musculoskeletal disorders
|November 26, 2024
概括
低老年人营养风险指数 (GNRI) 与患有2型糖尿病的老年人患骨质疏松症的风险更高有关. 使用GNRI进行营养评估可以帮助识别有风险的个体进行早期干预.
科学领域:
- 老年学是一门学科.
- 代谢障碍 代谢障碍 代谢障碍
- 骨和肌肉健康 骨和肌肉健康
背景情况:
- 骨质疏松症和骨质疏松症的双重状况骨质疏松症和骨质疏松症,在老龄化人口中构成重大健康风险.
- 营养状况,特别是老年营养风险指数 (GNRI) 与2型糖尿病 (T2DM) 患者的骨质缩症之间的关系仍然未得到充分研究.
研究的目的:
- 调查GNRI与诊断为T2DM的老年人中骨质沙症的患病率之间的关联.
- 确定GNRI是否可以在这个人口群体中作为骨质缩症的预测标志物.
主要方法:
- 一项涉及573名T2DM患者的横截面研究.
- 骨髓缩症通过使用双能X射线吸收计来评估骨矿物密度 (BMD) 和尾骨肌肉质量来诊断.
- 使用多变量分析,包括后勤回归来评估GNRI和骨硬化症之间的关联.
主要成果:
- 患有骨髓缩症的患者表现出最低的GNRI得分.
- 在多个部位,GNRI显示了与骨肌肉指数,握力,步行速度和BMD的正相关性.
- 低GNRI显着与骨质沙症的风险增加有关 (经调整的OR,4.164).
- 将GNRI纳入一个随年龄增长的模型,改善了骨髓缩症的辨别能力 (AUC从0.764增加到0.842).
结论:
- 低GNRI是患有T2DM的老年人骨髓硬化症的重要危险因素.
- 在老年糖尿病人群中,GNRI是一个有价值和简单的工具,用于早期识别老年糖尿病人群中患有骨髓缩症高风险的个体.
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