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Updated: Jun 6, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

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对Adagrasib药物相互作用的临床和生理学基础的药物动力学模型评估

Cornelius Cilliers1, Eleanor Howgate2, Hannah M Jones2

  • 1Clinical Pharmacology and Nonclinical Development, Mirati Therapeutics Inc. (A Bristol Myers Squib Company), San Diego, California, USA.

Clinical pharmacology and therapeutics
|November 26, 2024
PubMed
概括

阿达格拉西布是一种KRAS G12C抑制剂,由于抑制CYP3A4,具有药物相互作用的风险. 一个PBPK模型预测了adapgrasib.

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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

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A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction00:05

A Semi-Quantitative Drug Affinity Responsive Target Stability DARTS assay for studying Rapamycin/mTOR interaction

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