口腔潜在恶性疾病的抗核阳性和恶性转变潜力
Seok Woo Hong1, Jeong-Hyun Kang2,3
1Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Oral diseases
|November 26, 2024
概括
抗核抗体 (ANA) 阳性显著增加了患有口腔潜在恶性疾病 (OPMDs) 的患者恶性转变的风险. 这一发现突显了ANA作为口腔癌发展的关键预后标志物.
科学领域:
- 口腔病理学和瘤学
- 免疫学 免疫学 免疫学
- 生物统计学和流行病学
背景情况:
- 口腔潜在恶性疾病 (OPMDs) 携带进展到口腔状细胞癌 (OSCC) 的风险.
- 确定OPMD可靠的预后标志物对于早期干预和改善患者结果至关重要.
- 反核抗体 (ANA) 阳性在OPMD恶性转变中的作用仍在调查中.
研究的目的:
- 调查在被诊断为OPMDs的患者中ANA阳性和恶性转变风险之间的关联.
- 为了利用来自观察医学结果伙伴关系 (OMOP) 共同数据模型 (CDM) 的现实数据进行可靠的分析.
- 确定ANA阳性是否作为OPMD进展到OSCC的显著预后指标.
主要方法:
- 追溯性队列研究分析了来自五个医疗中心的数据.
- 使用考克斯回归和1:4倾向得分匹配进行队列比较.
- 对危险比率的综合元分析,以评估ANA阳性对OSCC风险的影响.
主要成果:
- 总共有27,984名OPMD患者被纳入;4.65%经历了恶性转变.
- 在倾向分数匹配后,分析了523名ANA阳性和1598名ANA阴性患者.
- 分析显示,与ANA阴性相比,ANA阳性显著增加了恶性转变的风险.
结论:
- 抗核抗体 (ANA) 阳性是预测OPMDs恶性转变的重要预后标记.
- 这些发现表明,在OPMD患者的风险分层和管理中,应考虑ANA状态.
- 进一步的研究可能会探索将ANA阳性与口腔癌发展联系在一起的潜在机制.
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