献血者血管血管反应的危险因素:系统性审查和元分析
Yaning Wu1,2,3, Hongchao Qi1,2,3, Emanuele Di Angelantonio1,2,3,4,5,6
1British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Transfusion
|November 26, 2024
概括
献血期间的血管反应 (VVR) 与女性性别,新捐赠者身份,年龄较小和血压较低有关. 了解这些风险因素可以提高捐赠者的安全性和保留.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 血管血管反应 (VVRs) 可以导致伤害,并阻止未来的献血.
- 之前的研究已经确定了VR风险因素,但它们的关联缺乏系统的评估.
- 本综述综合了自愿全血献血者VVR风险因素的证据.
研究的目的:
- 系统地评估和综合有关血液供献者血管反应相关风险因素的证据.
- 评估已识别的VVR风险因素的一致性,规模和有效性.
主要方法:
- 在2024年2月之前发表的英语语言研究的系统文献搜索.
- 包括71项研究与1900万捐赠.
- 随机效应的元分析和风险因素的叙事合成.
主要成果:
- 女性性别,新捐赠者身份,年龄较小,血液体积较小和血压较低与增加的VVR风险有关.
- 与捐赠相关的恐惧,焦虑和厌恶也与更高的VVR风险相关.
- 在大多数风险因素中发现了很高的异质性 (I2>90%).
结论:
- 这一元分析证实了已知的VVR风险因素,并突出了它们的异质关联.
- 研究结果支持完善供体选择标准和预防性干预措施.
- 需要大规模的研究来进行全面的多变量分析,以提高捐赠者的安全性.
关键词:
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