在澳大利亚成年人中使用TPMT测试的利用率和相关因素:一项全国追溯数据链接研究
Chin Hang Yiu1,2, Bella D Ianni1,2,3, Kenji Fujita4
1The University of Sydney School of Pharmacy, Camperdown, New South Wales, Australia.
Pharmacotherapy
|November 26, 2024
概括
对于提奥普林使用者来说,推进行TPMT测试,以预防不良药物反应,但只有32.5%的澳大利亚患者接受了它. 专家处方和城市位置与更高的测试率有关.
科学领域:
- 药物基因组学 药物基因组学
- 临床药理学 临床药理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 硫氨酸S-甲基转移酶 (TPMT) 代谢硫氨酸药物;活性降低需要TPMT测试以防止严重的药物不良反应.
- 临床上建议对开始治疗氨酸的患者进行TPMT测试,以减轻毒性风险.
研究的目的:
- 为了确定在澳大利亚人中测试氨酸甲基转移酶 (TPMT) 的速率,处方氨酸药物.
- 调查与这一群体接受TPMT测试相关的因素.
主要方法:
- 一项回顾性队列研究,使用2011-2022年澳大利亚行政数据 (制药福利计划,医疗保险福利计划,人口普查).
- 鉴定了62,574名患有硫黄素的使用者 (年龄≥18岁),并评估了TPMT测试率.
- 多变量逻辑回归分析了与接受TPMT测试相关的因素.
主要成果:
- 在2011年至2022年期间,只有32.5%的流行西奥普林使用者 (20,327/62,574) 接受了TPMT测试.
- 测试与专家处方 (aOR 2.12),非英语家庭语言 (aOR 1.29),没有慢性疾病 (aOR 1.18),没有核心活动援助需求 (aOR 1.16) 和高等教育 (aOR 1.11) 有显著的关联.
- 与大城市的人相比,偏远地区的个人接受测试的可能性较低 (aOR 0.49).
结论:
- 该研究显示,澳大利亚对TPMT测试的使用率很低,这表明在推的药物基因组实践中存在重大差距.
- 测试率存在差异,受处方者专业,社会经济地位和地理位置等因素的影响.
- 需要有针对性的干预措施来提高TPMT测试率,并解决氨酸药基因组测试中的不平等问题.
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