阿贝马西克利布诱导的间歇性肺部疾病的组织病理学:第一个跨支气管肺部冷藏活检的病例报告
Shota Kaburaki1, Toru Tanaka1, Akari Murata1
1Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
本案例报告详细介绍了一名患者,该患者从乳腺癌药物abemaciclib中发展出药物诱导的间歇性肺病 (DI-ILD). 经支气管肺冷活检证实了一种罕见的纤维化组织性肺炎模式,突显了对CDK4/6抑制剂的警的必要性.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 病理学 病理学 病理学
背景情况:
- 阿贝马西克利布是一种依赖于环林的激酶4/6抑制剂,用于激素受体阳性,HER2阴性转移性或复发性乳腺癌.
- 药物诱导的间歇性肺病 (DI-ILD) 是与abemaciclib治疗相关的潜在不良事件.
研究的目的:
- 报告一个由abemaciclib诱导的ILD病例,呈现为纤维化组织性肺炎.
- 突出跨支气管肺冷活检 (TBLC) 在怀疑DI-ILD的诊断效用.
- 扩大对与abemaciclib治疗相关的肺部不良事件的理解.
主要方法:
- 一个病例报告,一名82岁的女性患有乳腺癌,接受了abemaciclib的治疗.
- 使用了临床表现,诊断成像 (胸部HRCT) 和横支气管肺冷活检 (TBLC).
- 进行了肺组织的组织病理学检查.
主要成果:
- 患者出现了持续的咳和不适,最初怀疑是肺炎.
- 在TBLC中发现了纤维化组织性肺炎,证实了abemaciclib诱导的ILD.
- 停止使用abemaciclib导致症状显著改善.
结论:
- 这是第一个在abemaciclib诱导的ILD中报告的纤维化组织性肺炎病例.
- 通过提供详细的病学发现,TBLC可以对诊断DI-ILD有价值.
- 早期诊断和管理,可能涉及纤维化组织性肺炎的皮质类固醇,可以改善abemaciclib诱导的ILD的预后.
更多相关视频
06:29Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo
Published on: May 5, 2023
04:10Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
Published on: July 19, 2024
相关概念视频
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Pneumothorax II: Pathophysiology
Atelectasis II: Pathophysiology
Pneumonia I: Introduction
