肥胖和便秘之间的因果关系:一个双样本双向的门德尔随机化研究和元分析.
Xian Sun1, Shuoqiu Zhang2, Xi Zhou1
1School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in nutrition
|November 26, 2024
概括
肥胖,特别是遗传倾向的肥胖,增加了便秘的风险. 这项孟德尔随机化 (MR) 研究和元分析证实了因果关系,特别是在儿童中,突出了对潜在机制的进一步研究的需要.
科学领域:
- 遗传学和流行病学
- 胃肠病学和公共卫生
背景情况:
- 观察性研究表明,肥胖和便秘之间存在联系,但研究结果是矛盾的.
- 一个强大的因果关系需要超越观察数据的调查.
研究的目的:
- 使用孟德尔随机化 (MR) 评估遗传倾向性肥胖和便秘风险之间的因果关系.
- 进行元分析以确认发现并探索子组变异.
主要方法:
- 两个样本的孟德尔随机化 (MR) 研究利用全基因组关联研究 (GWAS) 肥胖 (BMI,WC,WHR,HC) 和便秘的数据.
- 14项符合条件的研究 (43,488名受试者) 的系统审查和元分析.
- 敏感性分析和E值计算,以确保结果的可靠性,并评估潜在的混.
主要成果:
- 核磁共振分析表明,体重指数 (BMI) 和腰围 (WC) 的增加因果关系上会增加便秘风险 (例如,IVW或BMI=1.138,p=0.012).
- 分析显示,肥胖和超重显著增加便秘风险 (RR=1.145),特别是在儿童中 (肥胖RR=1.407).
- 在成年人中,便秘和肥胖之间,或在WHR/HC和便秘之间没有发现显著的因果关系.
结论:
- 遗传倾向的肥胖,特别是更高的BMI和WC,与便秘的风险增加有关.
- 这些发现在MR和元分析中一致,在儿科患者群体中观察到显著的影响.
- 需要进一步的研究来阐明肥胖与便秘相关的机制.
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