在COVID-19之后,嗅觉训练对慢性嗅觉障碍的有效性:系统性审查
Natalia Treder-Rochna1, Aleksandra Mańkowska1, Wiktoria Kujawa1
1Faculty of Social Sciences, Institute of Psychology, University of Gdansk, Gdansk, Poland.
Frontiers in human neuroscience
|November 26, 2024
概括
嗅觉训练 (OT) 显著改善COVID-19后的慢性嗅觉障碍. 将OT与辅助疗法结合起来,并坚持至少三个月的协议,可以促进病毒后嗅觉功能障碍的恢复.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 慢性嗅觉障碍是COVID-19的常见后果.
- 后病毒性嗅觉功能障碍 (PVOD) 显著影响生活质量.
- 嗅觉训练 (OT) 是PVOD的主要治疗方法.
研究的目的:
- 评估COVID-19后患有慢性嗅觉障碍的患者的嗅觉训练的有效性.
- 评估单独的嗅觉训练与联合疗法的影响.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,EBSCOhost,Cochrane Library) 进行了系统的文献搜索,遵循PRISMA指南.
- 包括的研究集中在持续30天或更长时间的嗅觉障碍患者身上.
- 主要结局是使用客观心理物理测试,特别是Sniffin' Sticks的嗅觉得分的变化.
主要成果:
- 审查了14项涉及1596名参与者的研究,其中包括10项随机对照试验.
- 嗅觉训练本身就显示了嗅觉功能的显著改善.
- 联合治疗 (OT与辅助剂,如CoUltraPEALut,Cerebrolysin,维生素A) 显示出更好的结果.
结论:
- 嗅觉训练对于COVID-19后的慢性嗅觉功能障碍是有效的.
- 综合治疗方法在病毒后嗅觉功能障碍方面产生了优异的结果.
- 遵守OT协议和持续时间 (≥3个月) 对于最佳治疗结果至关重要.
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