在患有大血管封闭症的患者中H型高血压的值
Dongjing Xie1, Junfang Wan2,3, Changwei Guo1
1Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, People's Republic of China.
Clinical interventions in aging
|November 26, 2024
概括
患有H型高血压的患者,其特点是高水平的同类半氨酸,在大血管封闭性中风的内血管治疗后,出现积极结果的可能性较低. 然而,这种情况不会在90天内增加死亡率.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 脑卒中研究 脑卒中研究
背景情况:
- 内血管治疗 (EVT) 改善了急性大血管封闭 (LVO) 卒中的结果.
- 然而,许多成功实现再通道治疗的患者仍然经历不良结果.
- 特定高血压亚型在EVT后预后中的作用需要进一步研究.
研究的目的:
- 调查H型高血压与接受EVT的LVO患者的临床预后之间的关联.
- 为了确定H型高血压是否影响功能结果,死亡率或EVT后的并发症.
主要方法:
- 从RESCUE BT试验中对患者的分析.
- H型高血压定义为高血压和同类氨酸 (Hcy) ≥10μmol/L的同时发生.
- 主要结局:有利的功能结局 (修改的兰金尺度0-2在90天). 二次结局:死亡率,再通道成功/徒劳,症状性脑内出血 (sICH).
主要成果:
- 在215名高血压患者中,172名 (80%) 患有H型高血压.
- 增加的同类半氨酸水平与有利结果的概率下降相关.
- H型高血压与较低的有利结果几率显著相关 (aOR 0.38;p=0.01).
- 在H型高血压和死亡率 (p=0.23) 或sICH (p=0.41) 之间没有发现显著的关联.
结论:
- H型高血压与EVT后LVO患者的功能结果降低有关.
- 这种高血压亚型似乎不会增加90天死亡率或SICH风险.
- 控制类固醇氨酸水平对于改善这些患者的预后至关重要.
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