布伦图西马布诱导的急性间歇性炎:一个病例报告
Matthew Patterson1, Pouneh Dokouhaki2, Chance S Dumaine1
1Division of Nephrology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Canadian journal of kidney health and disease
|November 26, 2024
概括
用于某些淋巴瘤的Brentuximab vedotin很少会导致急性间歇性炎 (AIN),这是一种损伤. 这一案例突出了在接受布伦图西马布治疗的患者中AIN的新型遗传学发现.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 布伦图西马布 (Brentuximab vedotin) 是一种抗CD30抗体-药物结合物,已获批准用于治疗真菌菌菌病,霍奇金淋巴瘤和形大细胞淋巴瘤.
- 虽然一般耐受性很好,但脏并发症很少被报告.
- 急性损伤 (AKI) 是一种罕见但严重的潜在不良反应.
研究的目的:
- 报告一种罕见的急性间歇性炎 (AIN) 病例,该病例是布伦图西马布维多丁治疗的次要病例.
- 描述临床表现,诊断发现和治疗结果.
- 为突出药物诱导的AIN的一项新型本病理学发现.
主要方法:
- 一个73岁的男性患有真菌菌菌病的病例报告.
- 在布伦图西马布维多丁循环前后监测血清肌素和估计的淋巴球过率 (eGFR).
- 诊断AKI,排除其他原因,并通过脏活检确认AIN.
- 用口服普雷尼松治疗和随后的逐渐减少.
主要成果:
- 患者在第三次布伦图西马布维多丁循环后出现严重的AKI (SCr峰值为1073μmol/L).
- 活检证实了急性间歇性炎 (AIN) 与管间歇性炎症透.
- 用普得尼松治疗导致功能部分恢复 (SCr 156μmol/L).
- 组织病理与AIN一致,这种模式通常与免疫检查点抑制剂 (ICI) 相一致,尽管布伦图西马布不是ICI.
结论:
- 这种病例代表了brentuximab vedotin罕见的并发症,特别是急性间歇性炎.
- 对于非ICI药物来说,AIN在这种情况下的组织病理学发现是新鲜的.
- 医生应警布伦图西马布维多丁治疗的患者的脏不良事件,即使是罕见的.
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